Plague (Yersinia pestis)
1990 Case Definition
1990 Case Definition
Clinical Description
A disease characterized by fever and leukocytosis that presents in one or more of the following principal clinical forms:
- Regional lymphadenitis (bubonic plague)
- Septicemia without an evident bubo (septicemic plague)
- Plague pneumonia, resulting from hematogenous spread in bubonic or septicemic cases (secondary plague pneumonia ) or inhalation of infectious droplets (primary plague pneumonia)
- Pharyngitis and cervical lymphadenitis resulting from exposure to larger infectious droplets or ingestion of infected tissues (pharyngeal plague)
- Plague is transmitted to humans by fleas or by direct exposure to infected tissues or respiratory droplets.
Laboratory Criteria For Diagnosis
- Isolation of Yersinia pestis from a clinical specimen, OR
- Fourfold or greater change in serum antibody to Y. pestis
Case Classification
Probable
A clinically compatible illness with supportive laboratory results (demonstration of a single serologic test result suggestive of recent infection with no history of immunization, or demonstration of a Fraction I antigen in blood, bubo aspirate, or tissue by antigen detection -- enzyme-linked immunosorbent assay (ELISA) or fluorescent assay (FA)
Confirmed
A case that is laboratory confirmed