Rubella, Congenital Syndrome (CRS)
1990 Case Definition
1990 Case Definition
Clinical Description
An illness of newborns resulting from rubella infection in utero and characterized by symptoms from the following categories:
- Cataracts/congenital glaucoma, congenital heart disease, loss of hearing, pigmentary retinopathy
- Associated symptoms may be: purpura, splenomegaly, jaundice, microcephaly, mental retardation, meningoencephalitis, radiolucent bone disease
Clinical Criteria
Presence of any defects or laboratory data consistent with congenital rubella infection (as reported by a health professional)
Laboratory Criteria For Diagnosis
- Isolation of rubella virus, OR
- Demonstration of rubella-specific immunoglobulin M (IgM) antibody, OR
- An infant's rubella antibody level that persists above and beyond that expected from passive transfer of maternal antibody (i.e., rubella HI titer that does not drop at the expected rate of a twofold dilution per month)
Case Classification
Possible
A case with some compatible clinical findings but not meeting the criteria for a compatible case
Compatible
A case that is not laboratory confirmed and that has any two complications listed in (1) above, or one complication from (1) and one from (2)
Confirmed
A clinically compatible case that is laboratory confirmed
Comments
In compatible cases, either or both of the eye-related findings (cataracts and congenital glaucoma) count as a single complication.