CSTE Position Statement(s)
Clinical DescriptionAn acute illness with a discrete onset of any sign or symptom consistent with acute viral hepatitis (e.g., anorexia, abdominal discomfort, nausea, vomiting), and either a) jaundice, or b) serum alanine aminotransferase (ALT) levels >400 IU/L
Laboratory Criteria For Diagnosis
One or more of the following three criteria:
- Antibodies to hepatitis C virus (anti-HCV) screening-test-positive with a signal to cut-off ratio predictive of a true positive as determined for the particular assay as defined by CDC. (URL for the signal to cut-off ratios: https://www.cdc.gov/hepatitis/HCV/LabTesting.htm), OR
- Hepatitis C Virus Recombinant Immunoblot Assay (HCV RIBA) positive, OR
- Nucleic Acid Test (NAT) for HCV RNA positive
AND, meets the following two criteria:
- Immunoglobulin M antibody to hepatitis A virus (IgM anti-HAV) negative, AND
- IgM antibody to hepatitis B core antigen (IgM anti-HBc) negative
ConfirmedA case that meets the clinical case definition, is laboratory confirmed, and is not known to have chronic hepatitis C.
CommentsThe 2007 case definition appearing on this page was re-published in the 2009 CSTE position statement 09-ID-40. Thus, the 2007 and 2010 versions of the case definition are identical.
1. Kuo G, Choo Q-L, Alter HJ, Gitnick GL, Redeker AG, Purcell RH, Miyamura T, Dienstag JL, Alter MJ, Stevens CE, et al. An Assay for Cirulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis. Science 1989;244(4902):362-4