Rabies is an acute encephalomyelitis that almost always progresses to coma or death within 10 days after the first symptom.
Laboratory Criteria For Diagnosis
- Detection by direct fluorescent antibody of viral antigens in a clinical specimen (preferably the brain or the nerves surrounding hair follicles in the nape of the neck), OR
- Isolation (in cell culture or in a laboratory animal) of rabies virus from saliva, cerebrospinal fluid (CSF), or central nervous system tissue, OR
- Identification of a rabies-neutralizing antibody titer greater than or equal to 5 (complete neutralization) in the serum or CSF of an unvaccinated person.
A clinically compatible case that is laboratory confirmed
Laboratory confirmation by all of the above methods is strongly recommended.
The 1997 case definition appearing on this page was previously published in the 1990 MMWR Recommendations and Reports titled Case Definitions for Public Health Surveillance.1 Thus, the 1990 and 1997 versions of the case definition are identical.
- CDC. (1990). Case Definitions for Public Health Surveillance. MMWR, 39(RR-13), 1-43. https://www.cdc.gov/mmwr/preview/mmwrhtml/00025629.htm