Tularemia (Francisella tularensis)
2017 Case Definition
CSTE Position Statement(s)
- 16-ID-11
Clinical Criteria
An illness characterized by several distinct forms, including the following:
- Ulceroglandular: cutaneous ulcer with regional lymphadenopathy
- Glandular: regional lymphadenopathy with no ulcer
- Oculoglandular: conjunctivitis with preauricular lymphadenopathy
- Oropharyngeal: stomatitis or pharyngitis or tonsillitis and cervical lymphadenopathy
- Pneumonic: primary pulmonary disease
- Typhoidal: febrile illness without localizing signs and symptoms
Laboratory Criteria For Diagnosis
Supportive
- Elevated serum antibody titer(s) to F. tularensis antigen (without documented fourfold or greater change) in a patient with no history of tularemia vaccination, OR
- Detection of F. tularensis in a clinical or autopsy specimen by fluorescent assay, OR
- Detection of F. tularensis in a clinical or autopsy specimen by a polymerase chain reaction (PCR)
Confirmatory
- Isolation of F. tularensis in a clinical or autopsy specimen, OR
- Fourfold or greater change in serum antibody titer to F. tularensis antigen between acute and convalescent specimens