Hepatitis C, Chronic
2010 Case Definition
Hepatitis C, Chronic
2010 Case Definition
Print
2010 Case Definition
CSTE Position Statement(s)
- 09-ID-41
Clinical Description
Most hepatitis C virus (HCV)-infected persons are asymptomatic; however, many have chronic liver disease, which can range from mild to severe including cirrhosis and liver cancer.
Laboratory Criteria For Diagnosis
One or more of the following criteria:
- Anti-HCV positive (repeatedly reactive) by enzyme immunoassay (EIA) verified by at least one additional more specific assay, OR
- HCV-RIBA (recombinant immunoblot assay) positive, OR
- Nucleic Acid Test (NAT) for HCV RNA positive, OR
- Report of HCV genotype, OR
- Antibodies to hepatitis C virus (anti-HCV) screening-test-positive with a signal to cut-off ratio predictive of a true positive as determined for the particular assay and posted by CDC.1
Case Classification
Probable
A case that is anti-HCV positive (repeat reactive) by EIA and has alanine aminotransferase (ALT or serum glutamic pyruvic transaminase [SGPT]) values above the upper limit of normal, but the anti-HCV EIA result has not been verified by an additional more specific assay or the signal to cut-off ratio is unknown.
Confirmed
A case that is laboratory confirmed and does not meet the case definition for acute hepatitis C.
References
- Centers for Disease Control and Prevention [Internet]. Viral Hepatitis. [cited 2010 Sept 30]. Available from https://www.cdc.gov/hepatitis/HCV/LabTesting.htm.
Related Case Definition(s)
Last Reviewed: April 16, 2021