Clinical DescriptionMost hepatitis C virus (HCV)-infected persons are asymptomatic. However, many have chronic liver disease, which can range from mild to severe including cirrhosis and liver cancer.
Laboratory Criteria For Diagnosis
- Anti-HCV positive (repeat reactive) by enzyme immunoassay (EIA), verified by an additional more specific assay (e.g., recombinant immunoblot assay [RIBA] for anti-HCV or nucleic acid testing for HCV ribonucleic acid [RNA]), OR
- HCV RIBA positive, OR
- Nucleic acid test for HCV RNA positive, OR
- Report of HCV genotype, OR
- Anti-HCV screening-test-positive with a signal to cut-off ratio predictive of a true positive as determined for the particular assay (e.g., ≥3.8 for the EIA) as determined and posted by CDC.
ProbableA case that is anti-HCV positive (repeat reactive) by EIA and has alanine aminotranferase (ALT or SGPT) values above the upper limit of normal, but the anti-HCV EIA result has not been verified by an additional more specific assay or the signal to cutoff ratio is unknown.
ConfirmedA case that is laboratory confirmed and that does not meet the case definition for acute hepatitis C.
1. Centers for Disease Control and Prevention [Internet]. Viral Hepatitis. [cited 2010 Sept 30]. Available from https://www.cdc.gov/hepatitis/HCV/LabTesting.htm.