Coccidioidomycosis / Valley Fever (Coccidioides spp.)
2011 Case Definition
Coccidioidomycosis / Valley Fever (Coccidioides spp.)
2011 Case Definition
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2011 Case Definition
CSTE Position Statement(s)
- 10-ID-04
Clinical Criteria
Infection may be asymptomatic or may produce an acute or chronic disease. Although the disease initially resembles an influenza-like or pneumonia-like febrile illness primarily involving the bronchopulmonary system, dissemination can occur to multiple organ systems. An illness is typically characterized by one or more of the following:
- Influenza-like signs and symptoms (e.g., fever, chest pain, cough, myalgia, arthralgia, and headache)
- Pneumonia or other pulmonary lesion, diagnosed by chest radiograph
- Erythema nodosum or erythema multiforme rash
- Involvement of bones, joints, or skin by dissemination
- Meningitis
- Involvement of viscera and lymph nodes
Laboratory Criteria For Diagnosis
A confirmed case must meet at least one of the following laboratory criteria for diagnosis:
- Cultural, histopathologic, or molecular evidence of presence of Coccidioides species, OR
- Positive serologic test for coccidioidal antibodies in serum, cerebrospinal fluid, or other body fluids by:
- Detection of coccidioidal immunoglobulin M (IgM) by immunodiffusion, enzyme immunoassay (EIA), latex agglutination, or tube precipitin, OR
- Detection of coccidioidal immunoglobulin G (IgG) by immunodiffusion, EIA, or complement fixation, OR
- Coccidioidal skin-test conversion from negative to positive after onset of clinical signs and symptoms
Case Classification
Confirmed
A case that meets the clinical criteria and is laboratory confirmed.
Related Case Definition(s)
- Coccidioidomycosis / Valley Fever (Coccidioides spp.) | 2023 Case Definition
- Coccidioidomycosis / Valley Fever (Coccidioides spp.) | 2008 Case Definition
- Coccidioidomycosis / Valley Fever (Coccidioides spp.) | 1996 Case Definition
- Coccidioidomycosis / Valley Fever (Coccidioides spp.) | 1995 Case Definition
Last Reviewed: April 16, 2021